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Distinct pathways regulated by menin and by MLL1 in hematopoietic stem cells and developing B cells.

Abstract:

Mixed Lineage Leukemia (MLL1) translocations encode fusion proteins retaining the N terminus of MLL1, which interacts with the tumor suppressor, menin. This interaction is essential for leukemogenesis and thus is a promising drug target. However, wild-type MLL1 plays a critical role in sustaining hematopoietic stem cells (HSCs); therefore, disruption of an essential MLL1 cofactor would be expected to obliterate normal hematopoiesis. Here we show that rather than working together as a complex,...

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Journal:
Blood
Volume:
122
Issue:
12
Pages:
2039-2046
Publication date:
2013-09-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:1536b2dd-ebc8-43ac-86ae-2dd067bd49a0
Source identifiers:
441288
Local pid:
pubs:441288

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