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T cell receptor microcluster transport through molecular mazes reveals mechanism of translocation.

Abstract:

Recognition of peptide antigen by T cells involves coordinated movement of T cell receptors (TCRs) along with other costimulatory and signaling molecules. The spatially organized configurations that result are collectively referred to as the immunological synapse. Experimental investigation of the role of spatial organization in TCR signaling has been facilitated by the use of nanopatterned-supported membranes to direct TCR into alternative patterns. Here we study the mechanism by which subst...

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Publisher copy:
10.1529/biophysj.107.119099

Authors


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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
Journal:
Biophysical journal
Volume:
94
Issue:
8
Pages:
3286-3292
Publication date:
2008-04-05
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
URN:
uuid:15344b9c-8fce-4ba3-b551-9d8ac6cb4bec
Source identifiers:
426322
Local pid:
pubs:426322

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