Advances in human cardiac 31P-MR spectroscopy: SLOOP and clinical applications.

Journal article

Phosphorus magnetic resonance spectroscopy (31P-MRS) has revealed a lot about the biochemistry of physiological and pathological processes in the heart. Nevertheless, until today, cardiac 31P-MRS has not had any clinical impact, albeit some pioneering studies demonstrated that 31P-MRS can indeed provide diagnostic information. In this paper, the development of techniques for human cardiac 31P-MRS over the past decade is reviewed, and the requirements for a reliable clinical measurement protocol are discussed. Spatial localization with optimal pointspread function (SLOOP) is a new method to achieve spatial localization and absolute quantitation. Its properties are detailed, and preliminary findings in patients with dilated cardiomyopathy or myocardial infarction are presented.

Authors: von Kienlin, M; Beer, M; Greiser, A; Hahn, D; Harre, K

• Publication status: Published
• Journal: Journal of magnetic resonance imaging : JMRI
• Volume: 13
• Issue: 4
• Pages: 521-527
• Publication date: 2001-04-01
• DOI: 10.1002/jmri.1074
• EISSN: 1522-2586
• ISSN: 1053-1807
• Language: English
• Keywords: Magnetic Resonance Spectroscopy; Humans; Phosphorus Isotopes; Heart Diseases