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Evidence of a role of tumor necrosis factor alpha in refractory asthma.

Abstract:

BACKGROUND: The development of tumor necrosis factor alpha (TNF-alpha) antagonists has made it feasible to investigate the role of this cytokine in refractory asthma. METHODS: We measured markers of TNF-alpha activity on peripheral-blood monocytes in 10 patients with refractory asthma, 10 patients with mild-to-moderate asthma, and 10 control subjects. We also investigated the effects of treatment with the soluble TNF-alpha receptor etanercept (25 mg twice weekly) in the patients with refract...

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Publisher copy:
10.1056/nejmoa050580

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Journal:
The New England journal of medicine
Volume:
354
Issue:
7
Pages:
697-708
Publication date:
2006-02-05
DOI:
EISSN:
1533-4406
ISSN:
0028-4793
URN:
uuid:153335bf-39c4-44f6-bf10-a61bdf0c4dec
Source identifiers:
435306
Local pid:
pubs:435306

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