Journal article icon

Journal article

Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation.

Abstract:

We conducted a genome-wide association study to identify novel associations between genetic variants and circulating plasminogen activator inhibitor-1 (PAI-1) concentration, and examined functional implications of variants and genes that were discovered. A discovery meta-analysis was performed in 19 599 subjects, followed by replication analysis of genome-wide significant (P < 5 × 10(-8)) single nucleotide polymorphisms (SNPs) in 10 796 independent samples. We further examined associations...

Expand abstract
Publication status:
Published

Actions


Access Document


Authors


Expand authors...
Journal:
Blood
Volume:
120
Issue:
24
Pages:
4873-4881
Publication date:
2012-12-05
DOI:
EISSN:
1528-0020
ISSN:
0006-4971
URN:
uuid:1529c481-f468-4bda-8008-254f5c8ac5b4
Source identifiers:
352567
Local pid:
pubs:352567

Terms of use


Metrics


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP