- Abstract:
-
We conducted a genome-wide association study to identify novel associations between genetic variants and circulating plasminogen activator inhibitor-1 (PAI-1) concentration, and examined functional implications of variants and genes that were discovered. A discovery meta-analysis was performed in 19 599 subjects, followed by replication analysis of genome-wide significant (P < 5 × 10(-8)) single nucleotide polymorphisms (SNPs) in 10 796 independent samples. We further examined associations...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1182/blood-2012-06-436188
-
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- Journal:
- Blood
- Volume:
- 120
- Issue:
- 24
- Pages:
- 4873-4881
- Publication date:
- 2012-12-05
- DOI:
- EISSN:
-
1528-0020
- ISSN:
-
0006-4971
- URN:
-
uuid:1529c481-f468-4bda-8008-254f5c8ac5b4
- Source identifiers:
-
352567
- Local pid:
- pubs:352567
- Language:
- English
- Keywords:
- Copyright date:
- 2012
Journal article
Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation.
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