Journal article
A novel chimpanzee adenovirus vector with low human seroprevalence: improved systems for vector derivation and comparative immunogenicity.
- Abstract:
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Recombinant adenoviruses are among the most promising tools for vaccine antigen delivery. Recently, the development of new vectors has focused on serotypes to which the human population is less exposed in order to circumvent pre-existing anti vector immunity. This study describes the derivation of a new vaccine vector based on a chimpanzee adenovirus, Y25, together with a comparative assessment of its potential to elicit transgene product specific immune responses in mice. The vector was cons...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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(Preview, Version of record, pdf, 627.0KB, Terms of use)
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- Publisher copy:
- 10.1371/journal.pone.0040385
Authors
Funding
Bibliographic Details
- Publisher:
- Public Library of Science
- Journal:
- PloS one More from this journal
- Volume:
- 7
- Issue:
- 7
- Pages:
- e40385
- Publication date:
- 2012-01-01
- DOI:
- EISSN:
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1932-6203
- ISSN:
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1932-6203
Item Description
- Language:
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English
- Keywords:
- Pubs id:
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pubs:342309
- UUID:
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uuid:151053ee-b937-4f10-b02a-d84b7c6a3fd1
- Local pid:
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pubs:342309
- Source identifiers:
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342309
- Deposit date:
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2012-12-19
Terms of use
- Copyright holder:
- Dicks et al
- Copyright date:
- 2012
- Notes:
- Copyright: © 2012 Dicks et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
- Licence:
- CC Attribution (CC BY)
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