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18F-flutemetamol amyloid imaging in Alzheimer disease and mild cognitive impairment: a phase 2 trial.

Abstract:

OBJECTIVE: The most widely studied positron emission tomography ligand for in vivo beta-amyloid imaging is (11)C-Pittsburgh compound B ((11)C-PIB). Its availability, however, is limited by the need for an on-site cyclotron. Validation of the (18)F-labeled PIB derivative (18)F-flutemetamol could significantly enhance access to this novel technology. METHODS: Twenty-seven patients with early-stage clinically probable Alzheimer disease (AD), 20 with amnestic mild cognitive impairment (MCI), and...

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Publisher copy:
10.1002/ana.22068

Authors


Vandenberghe, R More by this author
Van Laere, K More by this author
Ivanoiu, A More by this author
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Journal:
Annals of neurology
Volume:
68
Issue:
3
Pages:
319-329
Publication date:
2010-09-05
DOI:
EISSN:
1531-8249
ISSN:
0364-5134
URN:
uuid:14fb3a8c-558c-4b7c-888f-b857d519e62b
Source identifiers:
429451
Local pid:
pubs:429451

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