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Journal article

Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3.

Abstract:

We conducted a two-stage genome-wide association study of renal cell carcinoma (RCC) in 3,772 affected individuals (cases) and 8,505 controls of European background from 11 studies and followed up 6 SNPs in 3 replication studies of 2,198 cases and 4,918 controls. Two loci on the regions of 2p21 and 11q13.3 were associated with RCC susceptibility below genome-wide significance. Two correlated variants (r² = 0.99 in controls), rs11894252 (P = 1.8 × 10⁻⁸) and rs7579899 (P = 2.3 × 10⁻⁹), map to E...

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Publication status:
Published

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Publisher copy:
10.1038/ng.723

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Journal:
Nature genetics
Volume:
43
Issue:
1
Pages:
60-65
Publication date:
2011-01-05
DOI:
EISSN:
1546-1718
ISSN:
1061-4036
URN:
uuid:14f863c8-639e-403a-a512-c97d4f2d87c3
Source identifiers:
107163
Local pid:
pubs:107163

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