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A BACwards glance at neurodegeneration: molecular insights into disease from LRRK2, SNCA and MAPT BAC-transgenic mice.

Abstract:

BAC (bacterial artificial chromosome)-transgenic mice expressing a transgene from an entire genomic locus under the control of the native promoter offer the opportunity to generate more accurate genetic models of human disease. The present review discusses results of recent studies investigating PD (Parkinson's disease) and tauopathies using BAC-transgenic mice carrying either the LRRK2 (leucine-rich repeat kinase 2), α-synuclein (SNCA) or MAPT (microtubule-associated protein tau) genes. In a...

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Publication status:
Published

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Publisher copy:
10.1042/bst0390862

Authors


Johnson, SJ More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Physiology Anatomy and Genetics
Journal:
Biochemical Society transactions
Volume:
39
Issue:
4
Pages:
862-867
Publication date:
2011-08-05
DOI:
EISSN:
1470-8752
ISSN:
0300-5127
URN:
uuid:14eb1592-cf6a-4f9b-84be-9a39c887d3a5
Source identifiers:
167534
Local pid:
pubs:167534

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