Thesis
Viral antagonism of extracellular cGAMP responses
- Abstract:
-
The presence of viral DNA outside of the nucleus is detected by the pattern recognition receptor cGAS during infection. cGAS then generates the cyclic dinucleotide 2’3’-cGAMP, which activates the central hub of DNA sensing – STING. This results in the production of proinflammatory cytokines, primarily type I interferons, driving antiviral responses.
Classically, 2’3’-cGAMP was thought to solely act within the cytosol, as its negative charge makes it membrane impermeable. Recently, ...
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Authors
Contributors
+ Rehwinkel, J
- Institution:
- University of Oxford
- Division:
- MSD
- Department:
- RDM
- Role:
- Supervisor
- ORCID:
- 0000-0003-3841-835X
+ Medical Research Council Weatherall Institute of Molecular Medicine
More from this funder
- Grant:
- CFR00620
- Programme:
- WIMM DPhil Studentship
- DOI:
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
- Language:
-
English
- Keywords:
- Subjects:
- Deposit date:
-
2023-07-10
Terms of use
- Copyright holder:
- Blest, HTW
- Copyright date:
- 2022
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