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Variation in MICA and MICB genes and enhanced susceptibility to paucibacillary leprosy in South India.

Abstract:

In a study of mainly paucibacillary leprosy-affected sib-pair families from South India, in addition to the expected associations with the HLA-DRB1 locus, we have identified significant association with a functional variant of the MICA gene as well as a microsatellite in the flanking region of the MICB gene. The associations with MICA and MICB cannot be accounted for by linkage disequilibrium with the HLA class II locus indicating a role in genetic susceptibility to leprosy that is independen...

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Publication status:
Published

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Publisher copy:
10.1093/hmg/ddl229

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, WTC Human Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Jenner Institute, Biomedical Research Centre
Role:
Author
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Journal:
Human molecular genetics
Volume:
15
Issue:
19
Pages:
2880-2887
Publication date:
2006-10-05
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
URN:
uuid:14d79485-95f6-40e8-86a7-3416e41288e1
Source identifiers:
33583
Local pid:
pubs:33583

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