Journal article icon

Journal article

Sudestada1, a Drosophila ribosomal prolyl-hydroxylase required for mRNA translation, cell homeostasis, and organ growth.

Abstract:

Genome sequences predict the presence of many 2-oxoglutarate (2OG)-dependent oxygenases of unknown biochemical and biological functions in Drosophila. Ribosomal protein hydroxylation is emerging as an important 2OG oxygenase catalyzed pathway, but its biological functions are unclear. We report investigations on the function of Sudestada1 (Sud1), a Drosophila ribosomal oxygenase. As with its human and yeast homologs, OGFOD1 and Tpa1p, respectively, we identified Sud1 to catalyze prolyl-hydrox...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1073/pnas.1314485111

Authors


Acevedo, JM More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Galagovsky, D More by this author
Expand authors...
Publisher:
National Academy of Sciences
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
111
Issue:
11
Pages:
4025-4030
Publication date:
2014-03-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:14d66e51-22b3-42e6-9100-a6282cadb1f2
Source identifiers:
449128
Local pid:
pubs:449128

Terms of use


Metrics



If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP