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Tracking epitope-specific antiviral CD4+ T cell responses to a live attenuated vaccine reveals ongoing functional responses.

Abstract:

There are few studies that have examined the frequencies of epitope-specific CD4(+) T cells following the use of a highly effective vaccine, yet such data would potentially be of value for the development of novel vaccination strategies. In this study we tracked human epitope-specific CD4(+) T cell responses over time after immunisation with a live attenuated varicella zoster virus vaccine by MHC Class II tetrameric complexes and functional assays. We show that the peptide-specific responses ...

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Publication status:
Published

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Publisher copy:
10.1016/j.vaccine.2009.08.081

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Primary Care Health Sciences
Role:
Author
Journal:
Vaccine More from this journal
Volume:
27
Issue:
52
Pages:
7398-7401
Publication date:
2009-12-01
DOI:
EISSN:
1873-2518
ISSN:
0264-410X

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