Journal article

Targeting intracellular mediators of pattern-recognition receptor signalling to adjuvant vaccination.

Abstract:: PRR (pattern-recognition receptor) signalling is involved early in the immune response and therefore would be attractive to target during vaccination. The use of PRR ligands has shown some success; however, toxicity and non-specificity are issues with this strategy. The targeting of PRR intracellular signalling networks would allow for greater specificity and reduced systemic toxicity. The present review examines the successes seen with overexpression or repression of PRR signalling molecules.

Publication status:: Published

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APA Style

Wales, J., Andreakos, E., Feldmann, M., & Foxwell, B. (2007). Targeting intracellular mediators of pattern-recognition receptor signalling to adjuvant vaccination. Biochemical Society Transactions, 35(Pt 6), 1501–1503.

MLA Style

Wales, J, et al. “Targeting Intracellular Mediators of Pattern-Recognition Receptor Signalling to Adjuvant Vaccination.” Biochemical Society Transactions, vol. 35, no. Pt 6, 2007, pp. 1501–03.

Chicago Style

Wales, J, E Andreakos, M Feldmann, and B Foxwell. 2007. “Targeting Intracellular Mediators of Pattern-Recognition Receptor Signalling to Adjuvant Vaccination.” Biochemical Society Transactions 35 (Pt 6): 1501–3.
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Publisher copy:: 10.1042/bst0351501

Authors

+ Wales, J More by this author

Role:: Author

+ Andreakos, E More by this author

Role:: Author

+ Feldmann, M More by this author

Institution:: University of Oxford
Division:: MSD
Department:: NDORMS
Role:: Author

+ Foxwell, B More by this author

Role:: Author

Journal:: Biochemical Society transactions More from this journal
Volume:: 35
Issue:: Pt 6
Pages:: 1501-1503
Publication date:: 2007-12-01
DOI:: 10.1042/bst0351501
EISSN:: 1470-8752
ISSN:: 0300-5127

Language:: English
Keywords:: Ligands

Adjuvants, Immunologic

Humans

Viral Vaccines

Receptors, Pattern Recognition

Immune System

Vaccines, DNA

Vaccination

Signal Transduction
Pubs id:: pubs:224916
UUID:: uuid:14caebdf-d0d4-4185-87e3-b286696790a2
Local pid:: pubs:224916
Source identifiers:: 224916
Deposit date:: 2012-12-19
ARK identifier:: ark:/29072/ora_14caebdfd0d4418587e3b286696790a2

Terms of use

Copyright date:: 2007

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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