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The productive entry pathway of HIV-1 in macrophages is dependent on endocytosis through lipid rafts containing CD4

Abstract:

Macrophages constitute an important reservoir of HIV-1 infection, yet HIV-1 entry into these cells is poorly understood due to the difficulty in genetically manipulating primary macrophages. We developed an effective genetic approach to manipulate the sub-cellular distribution of CD4 in macrophages, and investigated how this affects the HIV-1 entry pathway. Pluripotent Stem Cells (PSC) were transduced with lentiviral vectors designed to manipulate CD4 location and were then differentiated int...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1371/journal.pone.0086071

Authors


van Wilgenburg, B More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, Pathology Dunn School
Publisher:
Public Library of Science Publisher's website
Journal:
PLOS One Journal website
Volume:
9
Issue:
1
Pages:
e86071
Publication date:
2014-01-22
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
URN:
uuid:14c90161-b0b4-43a3-9229-d6e835bb2d2f
Source identifiers:
447868
Local pid:
pubs:447868

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