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Journal article

DNA aptamers for as analytical tools for the quantitative analysis of DNA-dealkylating enzymes.

Abstract:

The AlkB family of oxygenases catalyze the removal of alkyl groups from nucleic acid substrates in an iron and 2-oxoglutarate-dependent manner and have roles including in DNA repair. To understand the biological functions of these DNA-dealkylating enzymes it is desirable to measure their expression levels in vitro and in vivo in complex biological matrixes. Quantitative analyses of the enzymes require affinity probes capable of binding AlkB family members selectively and with high affinity. H...

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Publication status:
Published

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Publisher copy:
10.1016/j.ab.2011.03.010

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
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Journal:
Analytical biochemistry
Volume:
414
Issue:
2
Pages:
261-265
Publication date:
2011-07-01
DOI:
EISSN:
1096-0309
ISSN:
0003-2697
Source identifiers:
159336
Language:
English
Keywords:
Pubs id:
pubs:159336
UUID:
uuid:14c0646d-3de7-45bd-8647-693cf4d97cab
Local pid:
pubs:159336
Deposit date:
2012-12-19

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