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Journal article

DNA aptamers for as analytical tools for the quantitative analysis of DNA-dealkylating enzymes.

Abstract:

The AlkB family of oxygenases catalyze the removal of alkyl groups from nucleic acid substrates in an iron and 2-oxoglutarate-dependent manner and have roles including in DNA repair. To understand the biological functions of these DNA-dealkylating enzymes it is desirable to measure their expression levels in vitro and in vivo in complex biological matrixes. Quantitative analyses of the enzymes require affinity probes capable of binding AlkB family members selectively and with high affinity. H...

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Publication status:
Published

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Publisher copy:
10.1016/j.ab.2011.03.010

Authors


Krylova, SM More by this author
Karkhanina, AA More by this author
Musheev, MU More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
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Journal:
Analytical biochemistry
Volume:
414
Issue:
2
Pages:
261-265
Publication date:
2011-07-05
DOI:
EISSN:
1096-0309
ISSN:
0003-2697
URN:
uuid:14c0646d-3de7-45bd-8647-693cf4d97cab
Source identifiers:
159336
Local pid:
pubs:159336

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