R-loops induce repressive chromatin marks over mammalian gene terminators.

Journal article

The formation of R-loops is a natural consequence of the transcription process, caused by invasion of the DNA duplex by nascent transcripts. These structures have been considered rare transcriptional by-products with potentially harmful effects on genome integrity owing to the fragility of the displaced DNA coding strand. However, R-loops may also possess beneficial effects, as their widespread formation has been detected over CpG island promoters in human genes. Furthermore, we have previous...

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Authors: Skourti-Stathaki, K; Kamieniarz-Gdula, K; Proudfoot, N

• Publication status: Published
• Publisher: Nature Publishing Group
• Journal: Nature
• Volume: 516
• Issue: 7531
• Pages: 436-439
• Publication date: 2014-12-01
• DOI: 10.1038/nature13787
• EISSN: 1476-4687
• ISSN: 0028-0836
• Language: English
• Keywords: Actins; Cell Line; Hela Cells; Gene Expression Regulation; Histocompatibility Antigens; Mice; Chromatin; Animals; RNA Polymerase II; Argonaute Proteins; Terminator Regions, Genetic; Histone-Lysine N-Methyltransferase; Humans; RNA Interference; Histones