Carbonic anhydrase IX, an endogenous hypoxia marker, expression in head and neck squamous cell carcinoma and its relationship to hypoxia, necrosis, and microvessel density.

Journal article

Carbonic anhydrase IX (CA IX) is a transmembrane glycoprotein with an active extracellular enzyme site. We have shown previously that it was hypoxia inducible and may therefore be an endogenous marker of hypoxia. It is overexpressed in some tumors, particularly renal cell carcinoma. The aim of this study was to examine the expression and localization of CA IX in head and neck squamous cell carcinoma (HNSCC) and relate this to the location of tumor microvessels, angiogenesis, necrosis, and sta...

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Authors: Beasley, N; Wykoff, C; Watson, P; Leek, R; Turley, H

• Publication status: Published
• Journal: Cancer research
• Volume: 61
• Issue: 13
• Pages: 5262-5267
• Publication date: 2001-07-01
• EISSN: 1538-7445
• ISSN: 0008-5472
• Language: English
• Keywords: Microcirculation; Female; Cell Hypoxia; Blotting, Western; Antigens, Neoplasm; Tumor Cells, Cultured; Neoplasm Staging; Necrosis; Neovascularization, Pathologic; Enzyme Induction; Carbonic Anhydrases; Carcinoma, Squamous Cell; Middle Aged; Head and Neck Neoplasms; Male; Humans; Neoplasm Proteins