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Effect of stable glutamine compounds on porcine islet culture.

Abstract:

BACKGROUND: Pig islets are characterized by significant fragility, preventing successful islet culture prior to xenotransplantation. To improve outcome after culture, we compared the effects of glutamine supplementation on survival and viability of isolated pig islets during culture. METHODS: Pig islets were suspended in CMRL 1066 supplemented either with 2.5 mmol/L N-acetyl-L-alanyl-L-glutamine (NALG), a stable compound of L-glutamine, or with 2.5 or 5.0 mmol/L of free L-glutamine (L-Glu). A...

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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Role:
Author
Journal:
Transplantation proceedings
Volume:
37
Issue:
8
Pages:
3519-3520
Publication date:
2005-10-01
DOI:
EISSN:
1873-2623
ISSN:
0041-1345
Source identifiers:
273307
Language:
English
Keywords:
Pubs id:
pubs:273307
UUID:
uuid:14acc61c-9402-4045-824e-4ff5bd7a6570
Local pid:
pubs:273307
Deposit date:
2012-12-19

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