Extensive HLA-driven viral diversity following a narrow-source HIV-1 outbreak in rural China.

Journal article

Obstacles to developing an HIV-1 vaccine include extensive viral diversity and lack of correlates of protective immunity. High mutation rates allow HIV-1 to adapt rapidly to selective forces such as antiretroviral therapy and immune pressure, including HIV-1-specific CTLs that select viral variants which escape T-cell recognition. Multiple factors contribute to HIV-1 diversity, making it difficult to disentangle the contribution of CTL selection without using complex analytical approaches. We...

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Authors: Dong, T; Zhang, Y; Xu, K; Yan, H; James, I

• Publication status: Published
• Journal: Blood
• Volume: 118
• Issue: 1
• Pages: 98-106
• Publication date: 2011-07-01
• DOI: 10.1182/blood-2010-06-291963
• EISSN: 1528-0020
• ISSN: 0006-4971
• Language: English
• Keywords: Humans; HIV Integrase; Phylogeny; China; nef Gene Products, Human Immunodeficiency Virus; gag Gene Products, Human Immunodeficiency Virus; Genetic Variation; Epitopes, T-Lymphocyte; Adaptation, Physiological; Histocompatibility Antigens Class I; HIV Infections; Rural Population; HIV Reverse Transcriptase; Evolution, Molecular; Disease Outbreaks; Genotype; HIV-1