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Journal article

Bacteriophage biopanning in human tumour biopsies to identify cancer-specific targeting ligands.

Abstract:

Intravenous targeting of anticancer agents should improve both efficacy and therapeutic index. However, rational design of targeting constructs requires detailed definition of receptor targets and must take account of polarised tissue architecture that may restrict access to chosen receptors from the bloodstream. Bacteriophage biopanning provides a solution to this problem, identifying targeting sequences by functional selection rather than design, although reiterative panning in polarized hu...

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Publisher copy:
10.1080/10611860701195510

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Journal:
Journal of drug targeting
Volume:
15
Issue:
4
Pages:
311-319
Publication date:
2007-05-01
DOI:
EISSN:
1029-2330
ISSN:
1061-186X
Source identifiers:
178487
Language:
English
Keywords:
Pubs id:
pubs:178487
UUID:
uuid:14a97e64-1174-44e1-9052-9c1b324ae63a
Local pid:
pubs:178487
Deposit date:
2012-12-19

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