Preoperative p53, bcl-2, CD44 and E-cadherin immunohistochemistry as predictors of biochemical relapse after radical prostatectomy.

Journal article

Purpose

Since radical prostatectomy is performed to cure prostate cancer, identification of markers enabling preoperative prediction of relapse after radical prostatectomy is essential to counsel and select patients for adjuvant therapy. Aberrant p53, bcl-2, CD44 and E-cadherin immunohistochemistry has been associated with aggressiveness in prostate cancer. We assessed these biomarkers in biopsy and radical prostatectomy specimens as predictors of biochemical relapse.

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Authors: Brewster, S; Oxley, J; Trivella, M; Abbott, C; Gillatt, D

• Publication status: Published
• Peer review status: Peer reviewed
• Publisher: Elsevier Publisher's website
• Journal: Journal of Urology Journal website
• Volume: 161
• Issue: 4
• Pages: 1238-1243
• Publication date: 1999-04-01
• Acceptance date: 1998-10-02
• DOI: 10.1097/00005392-199904000-00058
• EISSN: 1527-3792
• ISSN: 0022-5347
• Language: English
• Keywords: predictive value of tests; proto-oncogene proteins c-bcl-2; preoperative care; antigens, CD44; survival rate; tumor suppressor protein p53; neoplasm recurrence, local; prostatectomy; risk factors; prostatic neoplasms; cadherins; genes, bcl-2; postoperative care; immunohistochemistry