Journal article
Transgenic overexpression of the type I isoform of neuregulin 1 affects working memory and hippocampal oscillations but not long-term potentiation.
- Abstract:
-
Neuregulin 1 (NRG1) is a growth factor involved in neurodevelopment and plasticity. It is a schizophrenia candidate gene, and hippocampal expression of the NRG1 type I isoform is increased in the disorder. We have studied transgenic mice overexpressing NRG1 type I (NRG1(tg-type I)) and their wild-type littermates and measured hippocampal electrophysiological and behavioral phenotypes. Young NRG1(tg-type I) mice showed normal memory performance, but in older NRG1(tg-type I) mice, hippocampus-d...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Bibliographic Details
- Publisher:
- Oxford University Press Publisher's website
- Journal:
- Cerebral cortex (New York, N.Y. : 1991) Journal website
- Volume:
- 22
- Issue:
- 7
- Pages:
- 1520-1529
- Publication date:
- 2012-07-01
- DOI:
- EISSN:
-
1460-2199
- ISSN:
-
1047-3211
Item Description
- Language:
- English
- Keywords:
- UUID:
-
uuid:14a5f585-378e-4d4a-9483-8ae4d9901269
- Local pid:
- pubs:172131
- Source identifiers:
-
172131
- Deposit date:
- 2012-12-19
Terms of use
- Copyright holder:
- Deakin et al
- Copyright date:
- 2012
- Notes:
- Copyright © 2011 Deakin et al. Published by Oxford University Press. This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs licence (http://creativecommons.org/licenses/by-nc/3.0/) which permits non-commercial reproduction and distribution of the work, in any medium, provided the original work is not altered or transformed in any way, and that the work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
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