- Abstract:
-
Protein aggregation, leading to amyloid deposition in the brain, is implicated in the pathology of a number of increasingly prevalent neurodegeneration states such as Parkinson's disease (PD), Alzheimer's disease and prion diseases. The body's protective response to the formation of such deposits is to generate specific autoimmune antibodies. Alpha-synuclein, a natively unfolded protein relatively abundant in the brain, is the main constituent of Lewy body amyloid dispositions in PD. Previous...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1039/c2sc21221h
-
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- Journal:
- CHEMICAL SCIENCE
- Volume:
- 3
- Issue:
- 12
- Pages:
- 3468-3473
- Publication date:
- 2012-12-05
- DOI:
- EISSN:
-
2041-6539
- ISSN:
-
2041-6520
- URN:
-
uuid:149f0fcf-813a-4eaf-9809-e8ad46abdcd7
- Source identifiers:
-
359704
- Local pid:
- pubs:359704
- Copyright date:
- 2012
Journal article
The robust electrochemical detection of a Parkinson's disease marker in whole blood sera
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