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Journal article

The robust electrochemical detection of a Parkinson's disease marker in whole blood sera

Abstract:

Protein aggregation, leading to amyloid deposition in the brain, is implicated in the pathology of a number of increasingly prevalent neurodegeneration states such as Parkinson's disease (PD), Alzheimer's disease and prion diseases. The body's protective response to the formation of such deposits is to generate specific autoimmune antibodies. Alpha-synuclein, a natively unfolded protein relatively abundant in the brain, is the main constituent of Lewy body amyloid dispositions in PD. Previous...

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Publication status:
Published

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Publisher copy:
10.1039/c2sc21221h

Authors


Forsgren, L More by this author
Morozova-Roche, LA More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Inorganic Chemistry
Journal:
CHEMICAL SCIENCE
Volume:
3
Issue:
12
Pages:
3468-3473
Publication date:
2012-12-05
DOI:
EISSN:
2041-6539
ISSN:
2041-6520
URN:
uuid:149f0fcf-813a-4eaf-9809-e8ad46abdcd7
Source identifiers:
359704
Local pid:
pubs:359704

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