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Use of Tag single nucleotide polymorphisms (SNPs) to screen PTPN21: no association with Graves' disease.

Abstract:

OBJECTIVE: The protein-tyrosine-phosphate nonreceptor 22 gene (PTPN22) has recently been identified as a susceptibility locus for a number of autoimmune diseases including Graves' disease (GD). PTPN21 is another member of the PTPN family and its gene PTPN21 maps to the first reported region of genetic linkage to GD, GD-1, on chromosome 14q31. The aim of this study was to determine whether PTPN21 is acting as a GD susceptibility locus in UK Caucasian subjects. DESIGN: A case control associatio...

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Publication status:
Published

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Authors


Zeitlin, AA More by this author
Heward, JM More by this author
Franklyn, JA More by this author
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Journal:
Clinical endocrinology
Volume:
65
Issue:
3
Pages:
380-384
Publication date:
2006-09-05
DOI:
EISSN:
1365-2265
ISSN:
0300-0664
URN:
uuid:149eb55c-d011-4269-b209-3a2cb6943a54
Source identifiers:
176323
Local pid:
pubs:176323

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