Common variation at the 11-β hydroxysteroid dehydrogenase type 1 gene is associated with left ventricular mass.

Journal article

BACKGROUND: Polymorphisms in 11-β hydroxysteroid dehydrogenase type 1 (11β-HSD1, encoded by HSD11B1) have been reported to be associated with obesity-related cardiovascular risk factors, such as type II diabetes and hypertension. Left ventricular hypertrophy (LVH) is an independent risk factor for cardiovascular death associated with these factors but has significant additional heritability, the cause of which is undetermined. The 11β-HSD1 is believed to maintain tonic inhibition of the miner...

Expand abstract

Authors: Rahman, T; Mayosi, B; Hall, D; Avery, P; Stewart, P

• Publication status: Published
• Journal: Circulation. Cardiovascular genetics
• Volume: 4
• Issue: 2
• Pages: 156-162
• Publication date: 2011-04-01
• DOI: 10.1161/circgenetics.110.958496
• EISSN: 1942-3268
• ISSN: 1942-325X
• Language: English
• Keywords: Blood Pressure; Female; Adult; Body Mass Index; Polymorphism, Single Nucleotide; 11-beta-Hydroxysteroid Dehydrogenase Type 1; Male; Hypertrophy, Left Ventricular; Electrocardiography; Adolescent; Genotype; Receptors, Mineralocorticoid; Hypertension; Risk Factors; Mass Spectrometry; Aged, 80 and over; Middle Aged; Humans; Aged