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Journal article

Nonstandard peptide binding revealed by crystal structures of HLA-B*5101 complexed with HIV immunodominant epitopes.

Abstract:

The crystal structures of the human MHC class I allele HLA-B*5101 in complex with 8-mer, TAFTIPSI, and 9-mer, LPPVVAKEI, immunodominant peptide epitopes from HIV-1 have been determined by x-ray crystallography. In both complexes, the hydrogen-bonding network in the N-terminal anchor (P1) pocket is rearranged as a result of the replacement of the standard tyrosine with histidine at position 171. This results in a nonstandard positioning of the peptide N terminus, which is recognized by B*5101-...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.165.6.3260

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, Structural Biology
Role:
Author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
165
Issue:
6
Pages:
3260-3267
Publication date:
2000-09-05
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:148fe267-0ef4-4601-aa9c-d93e0634bd72
Source identifiers:
25971
Local pid:
pubs:25971

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