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Interaction of monotopic membrane enzymes with a lipid bilayer: a coarse-grained MD simulation study.

Abstract:

Monotopic membrane proteins bind tightly to cell membranes but do not generally span the lipid bilayer. Their interactions with lipid bilayers may be studied via coarse-grained molecular dynamics (CG-MD) simulations. Understanding such interactions is important as monotopic enzymes frequently act on hydrophobic substrates, while X-ray structures rarely provide direct information about their interactions with membranes. CG-MD self-assembly simulations enable prediction of the orientation and d...

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Publication status:
Published

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Publisher copy:
10.1021/bi8017398

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Journal:
Biochemistry
Volume:
48
Issue:
10
Pages:
2135-2145
Publication date:
2009-03-05
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
URN:
uuid:148557d3-e1dd-4293-b963-f7f9086499e5
Source identifiers:
100828
Local pid:
pubs:100828

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