Journal article
Peptide modification or blocking of CD8, resulting in weak TCR signaling, can activate CTL for Fas- but not perforin-dependent cytotoxicity or cytokine production.
- Abstract:
-
This study describes a form of partial agonism for a CD8+ CTL clone, S15, in which perforin-dependent killing and IFN-gamma production were lost but Fas (APO1 or CD95)-dependent cytotoxicity preserved. Cloned S15 CTL are H-2Kd restricted and specific for a photoreactive derivative of the Plasmodium berghei circumsporozoite peptide PbCS 252-260 (SYIPSAEKI). The presence of a photoactivatable group in the epitope permitted assessment of TCR-ligand binding by TCR photoaffinity labeling. Selectiv...
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- Publication status:
- Published
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Bibliographic Details
- Journal:
- Journal of immunology (Baltimore, Md. : 1950)
- Volume:
- 161
- Issue:
- 12
- Pages:
- 6939-6946
- Publication date:
- 1998-12-05
- EISSN:
-
1550-6606
- ISSN:
-
0022-1767
- URN:
-
uuid:14772ca3-1f0a-4eeb-b418-d953336ce305
- Source identifiers:
-
9922
- Local pid:
- pubs:9922
Item Description
- Language:
- English
- Keywords:
Terms of use
- Copyright date:
- 1998
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