Peptide modification or blocking of CD8, resulting in weak TCR signaling, can activate CTL for Fas- but not perforin-dependent cytotoxicity or cytokine production.

Kessler, B; Hudrisier, D; Schroeter, M; Tschopp, J; Cerottini, JC; Luescher, IF

Abstract:

This study describes a form of partial agonism for a CD8+ CTL clone, S15, in which perforin-dependent killing and IFN-gamma production were lost but Fas (APO1 or CD95)-dependent cytotoxicity preserved. Cloned S15 CTL are H-2Kd restricted and specific for a photoreactive derivative of the Plasmodium berghei circumsporozoite peptide PbCS 252-260 (SYIPSAEKI). The presence of a photoactivatable group in the epitope permitted assessment of TCR-ligand binding by TCR photoaffinity labeling. Selectiv...

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Published

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APA Style

Kessler, B., Hudrisier, D., Schroeter, M., Tschopp, J., Cerottini, J. C., & Luescher, I. F. (1998). Peptide modification or blocking of CD8, resulting in weak TCR signaling, can activate CTL for Fas- but not perforin-dependent cytotoxicity or cytokine production. Journal of Immunology (Baltimore, Md. : 1950), 161(12), 6939–6946.

MLA Style

Kessler, B., et al. “Peptide Modification or Blocking of CD8, Resulting in Weak TCR Signaling, Can Activate CTL for Fas- but Not Perforin-Dependent Cytotoxicity or Cytokine Production.” Journal of Immunology (Baltimore, Md. : 1950), vol. 161, no. 12, Journal of immunology (Baltimore, Md. : 1950), 1998, pp. 6939–46.

Chicago Style

Kessler, B, D Hudrisier, M Schroeter, J Tschopp, JC Cerottini, and IF Luescher. 1998. “Peptide Modification or Blocking of CD8, Resulting in Weak TCR Signaling, Can Activate CTL for Fas- but Not Perforin-Dependent Cytotoxicity or Cytokine Production.” Journal of Immunology (Baltimore, Md. : 1950) 161 (12): 6939–46.
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Authors

+ Kessler, B More by this author

Institution:

University of Oxford

Department:

Oxford, MSD, Clinical Medicine, CCMP

Hudrisier, D More by this author

Schroeter, M More by this author

Tschopp, J More by this author

Cerottini, JC More by this author

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Bibliographic Details

Journal:: Journal of immunology (Baltimore, Md. : 1950)
Volume:: 161
Issue:: 12
Pages:: 6939-6946
Publication date:: 1998-12-05
EISSN:: 1550-6606
ISSN:: 0022-1767
URN:: uuid:14772ca3-1f0a-4eeb-b418-d953336ce305
Source identifiers:: 9922
Local pid:: pubs:9922

Item Description

Language:: English
Keywords:: Protein Processing, Post-Translational

Antigens, CD8

Perforin

Pore Forming Cytotoxic Proteins

Protozoan Proteins

Enzyme Inhibitors

Benzoquinones

Fas Ligand Protein

Cytotoxicity, Immunologic

Peptide Fragments

Interferon-gamma

Membrane Proteins

H-2 Antigens

Immunoglobulin Fab Fragments

Mast-Cell Sarcoma

Calcium Signaling

Lymphocyte Specific Protein Tyrosine Kinase p56(lck)

Mice

Azides

Lymphocyte Activation

Clone Cells

Animals

T-Lymphocytes, Cytotoxic

Plasmodium berghei

Lactams, Macrocyclic

Phosphorylation

Protein-Tyrosine Kinases

Quinones

Salicylic Acids

Antigens, CD95

Photoaffinity Labels

Antibodies, Monoclonal

Membrane Glycoproteins

Receptors, Antigen, T-Cell

ZAP-70 Protein-Tyrosine Kinase

Epitopes

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