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Peptide modification or blocking of CD8, resulting in weak TCR signaling, can activate CTL for Fas- but not perforin-dependent cytotoxicity or cytokine production.

Abstract:

This study describes a form of partial agonism for a CD8+ CTL clone, S15, in which perforin-dependent killing and IFN-gamma production were lost but Fas (APO1 or CD95)-dependent cytotoxicity preserved. Cloned S15 CTL are H-2Kd restricted and specific for a photoreactive derivative of the Plasmodium berghei circumsporozoite peptide PbCS 252-260 (SYIPSAEKI). The presence of a photoactivatable group in the epitope permitted assessment of TCR-ligand binding by TCR photoaffinity labeling. Selectiv...

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Publication status:
Published

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP
Hudrisier, D More by this author
Schroeter, M More by this author
Tschopp, J More by this author
Cerottini, JC More by this author
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Journal:
Journal of immunology (Baltimore, Md. : 1950)
Volume:
161
Issue:
12
Pages:
6939-6946
Publication date:
1998-12-05
EISSN:
1550-6606
ISSN:
0022-1767
URN:
uuid:14772ca3-1f0a-4eeb-b418-d953336ce305
Source identifiers:
9922
Local pid:
pubs:9922

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