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Lack of effect of a single dose of hydrocortisone on serotonin(1A) receptors in recovered depressed patients measured by positron emission tomography with [11C]WAY-100635.

Abstract:

BACKGROUND: Elevated cortisol levels might account for the reduction in central serotonin 1A (5-hydroxytryptamine [5-HT](1A)) receptor binding and function observed in patients with major depression. We tested this hypothesis by studying the effect of acute administration of hydrocortisone on 5-HT(1A) receptor binding potential (BP) in subjects recovered from depression. METHODS: We studied 14 subjects (8 male, 6 female) who had recovered from at least two episodes of major depression and ha...

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Publication status:
Published

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Journal:
Biological psychiatry
Volume:
54
Issue:
9
Pages:
890-895
Publication date:
2003-11-01
DOI:
EISSN:
1873-2402
ISSN:
0006-3223
Source identifiers:
185855
Language:
English
Keywords:
Pubs id:
pubs:185855
UUID:
uuid:1470ca97-6b42-4034-9527-c4318564416a
Local pid:
pubs:185855
Deposit date:
2012-12-19

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