Antibodies to plant-produced Plasmodium falciparum sexual stage protein Pfs25 exhibit transmission blocking activity.

Journal article

Malaria is a serious and sometimes fatal mosquito-borne disease caused by a protozoan parasite. Each year, it is estimated that over one million people are killed by malaria, yet the disease is preventable and treatable. Developing vaccines against the parasite is a critical component in the fight against malaria and these vaccines can target different stages of the pathogen's life cycle. We are targeting sexual stage proteins of P. falciparum which are found on the surface of the parasite re...

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Authors: Farrance, C; Chichester, J; Musiychuk, K; Shamloul, M; Rhee, A

• Journal: Human vaccines
• Volume: 7 Suppl
• Issue: SUPPL.
• Pages: 191-198
• Publication date: 2011-01-01
• EISSN: 1554-8619
• ISSN: 1554-8600
• Language: English
• Keywords: Recombinant Proteins; Animals; Culicidae; Feeding Behavior; Plants, Genetically Modified; Malaria, Falciparum; Plasmodium falciparum; Disease Transmission, Infectious; Antibodies, Protozoan; Tobacco; Mice; Protozoan Proteins; Malaria Vaccines