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HIF hydroxylation and cellular oxygen sensing.

Abstract:

Hypoxia-inducible factor (HIF) is a transcriptional complex that mediates a broad range of cellular and systemic responses to hypoxia. Analysis of HIF-alpha subunits has demonstrated that its activity is regulated by a series of oxygen-dependent enzymatic hydroxylations at specific prolyl and asparaginyl residues. Combined structural/genetic approaches have identified the relevant enzymes as members of the 2-oxoglutarate-dependent dioxygenase superfamily, possessing a beta-barrel 'jelly-roll'...

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Publication status:
Published

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Publisher copy:
10.1515/bc.2004.016

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Institution:
University of Oxford
Department:
Oxford, MSD, Clinical Medicine, CCMP, Biomedical Research Centre
Volume:
385
Issue:
3-4
Pages:
223-230
Publication date:
2004
DOI:
EISSN:
1437-4315
ISSN:
1431-6730
URN:
uuid:1465fd52-cf4f-453b-afa4-4e50aff39bf2
Source identifiers:
17709
Local pid:
pubs:17709

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