- Abstract:
-
Hypoxia-inducible factor (HIF) is a transcriptional complex that mediates a broad range of cellular and systemic responses to hypoxia. Analysis of HIF-alpha subunits has demonstrated that its activity is regulated by a series of oxygen-dependent enzymatic hydroxylations at specific prolyl and asparaginyl residues. Combined structural/genetic approaches have identified the relevant enzymes as members of the 2-oxoglutarate-dependent dioxygenase superfamily, possessing a beta-barrel 'jelly-roll'...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1515/bc.2004.016
-
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- Volume:
- 385
- Issue:
- 3-4
- Pages:
- 223-230
- Publication date:
- 2004
- DOI:
- EISSN:
-
1437-4315
- ISSN:
-
1431-6730
- URN:
-
uuid:1465fd52-cf4f-453b-afa4-4e50aff39bf2
- Source identifiers:
-
17709
- Local pid:
- pubs:17709
- Copyright date:
- 2004
Conference
HIF hydroxylation and cellular oxygen sensing.
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