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Journal article

Cytoskeletal polarization and redistribution of cell-surface molecules during T cell antigen recognition.

Abstract:

T cell antigen recognition is accompanied by cytoskeletal polarization towards the APC and large-scale redistribution of cell surface molecules into 'supramolecular activation clusters' (SMACs), forming an organized contact interface termed the 'immunological synapse' (IS). Molecules are arranged in the IS in a micrometer scale bull's eye pattern with a central accumulation of TCR/peptide-MHC (the cSMAC) surrounded by a peripheral ring of adhesion molecules (the pSMAC). We propose that segreg...

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Publication status:
Published

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Publisher copy:
10.1006/smim.2000.0203

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Seminars in immunology
Volume:
12
Issue:
1
Pages:
5-21
Publication date:
2000-02-01
DOI:
EISSN:
1096-3618
ISSN:
1044-5323
Source identifiers:
30812
Language:
English
Keywords:
Pubs id:
pubs:30812
UUID:
uuid:1459ec87-e606-47dd-b26a-d23f87ef1389
Local pid:
pubs:30812
Deposit date:
2012-12-19

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