Journal article
Cytoskeletal polarization and redistribution of cell-surface molecules during T cell antigen recognition.
- Abstract:
-
T cell antigen recognition is accompanied by cytoskeletal polarization towards the APC and large-scale redistribution of cell surface molecules into 'supramolecular activation clusters' (SMACs), forming an organized contact interface termed the 'immunological synapse' (IS). Molecules are arranged in the IS in a micrometer scale bull's eye pattern with a central accumulation of TCR/peptide-MHC (the cSMAC) surrounded by a peripheral ring of adhesion molecules (the pSMAC). We propose that segreg...
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- Publication status:
- Published
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- Publisher copy:
- 10.1006/smim.2000.0203
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Authors
Bibliographic Details
- Journal:
- Seminars in immunology
- Volume:
- 12
- Issue:
- 1
- Pages:
- 5-21
- Publication date:
- 2000-02-01
- DOI:
- EISSN:
-
1096-3618
- ISSN:
-
1044-5323
- Source identifiers:
-
30812
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:30812
- UUID:
-
uuid:1459ec87-e606-47dd-b26a-d23f87ef1389
- Local pid:
- pubs:30812
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2000
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