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High-frequency stimulation of the subthalamic nucleus suppresses oscillatory beta activity in patients with Parkinson's disease in parallel with improvement in motor performance.

Abstract:

High-frequency stimulation (HFS) of the subthalamic nucleus (STN) is a well-established therapy for patients with severe Parkinson's disease (PD), but its mechanism of action is unclear. Exaggerated oscillatory synchronization in the beta (13-30 Hz) frequency band has been associated with bradykinesia in patients with PD. Accordingly, we tested the hypothesis that the clinical benefit exerted by STN HFS is accompanied by suppression of local beta activity. To this end, we explored the after e...

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Publication status:
Published

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Journal:
Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
28
Issue:
24
Pages:
6165-6173
Publication date:
2008-06-01
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
Source identifiers:
122478
Language:
English
Keywords:
Pubs id:
pubs:122478
UUID:
uuid:1449469b-72c6-4611-88f1-2fadaa269b58
Local pid:
pubs:122478
Deposit date:
2013-02-20

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