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High-frequency stimulation of the subthalamic nucleus suppresses oscillatory beta activity in patients with Parkinson's disease in parallel with improvement in motor performance.

Abstract:

High-frequency stimulation (HFS) of the subthalamic nucleus (STN) is a well-established therapy for patients with severe Parkinson's disease (PD), but its mechanism of action is unclear. Exaggerated oscillatory synchronization in the beta (13-30 Hz) frequency band has been associated with bradykinesia in patients with PD. Accordingly, we tested the hypothesis that the clinical benefit exerted by STN HFS is accompanied by suppression of local beta activity. To this end, we explored the after e...

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Publication status:
Published

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Authors


Brücke, C More by this author
Gaynor Doyle, L More by this author
Martinez-Torres, I More by this author
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Journal:
The Journal of neuroscience : the official journal of the Society for Neuroscience
Volume:
28
Issue:
24
Pages:
6165-6173
Publication date:
2008-06-05
DOI:
EISSN:
1529-2401
ISSN:
0270-6474
URN:
uuid:1449469b-72c6-4611-88f1-2fadaa269b58
Source identifiers:
122478
Local pid:
pubs:122478

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