- Abstract:
-
High-frequency stimulation (HFS) of the subthalamic nucleus (STN) is a well-established therapy for patients with severe Parkinson's disease (PD), but its mechanism of action is unclear. Exaggerated oscillatory synchronization in the beta (13-30 Hz) frequency band has been associated with bradykinesia in patients with PD. Accordingly, we tested the hypothesis that the clinical benefit exerted by STN HFS is accompanied by suppression of local beta activity. To this end, we explored the after e...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1523/jneurosci.0282-08.2008
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- Journal:
- The Journal of neuroscience : the official journal of the Society for Neuroscience
- Volume:
- 28
- Issue:
- 24
- Pages:
- 6165-6173
- Publication date:
- 2008-06-05
- DOI:
- EISSN:
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1529-2401
- ISSN:
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0270-6474
- URN:
-
uuid:1449469b-72c6-4611-88f1-2fadaa269b58
- Source identifiers:
-
122478
- Local pid:
- pubs:122478
- Copyright date:
- 2008
Journal article
High-frequency stimulation of the subthalamic nucleus suppresses oscillatory beta activity in patients with Parkinson's disease in parallel with improvement in motor performance.
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