Quantitative perfusion measurements using pulsed arterial spin labeling: effects of large region-of-interest analysis.

Journal article

PURPOSE: To study arterial spin labeling (ASL) MRI techniques and to investigate various problematic issues that still hinder the accurate and robust quantitative analysis of ASL data. MATERIALS AND METHODS: A pulsed-ASL (PASL) sequence was implemented on a 3-T imaging system and a protocol was developed for the measurement of perfusion based on fitting to a standard kinetic model. Both numerical simulations and multi-inversion time MRI data were analyzed. The effect of fitting a kinetic cur...

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Authors: Figueiredo, P; Clare, S; Jezzard, P

• Publication status: Published
• Journal: Journal of magnetic resonance imaging : JMRI
• Volume: 21
• Issue: 6
• Pages: 676-682
• Publication date: 2005-06-01
• DOI: 10.1002/jmri.20329
• EISSN: 1522-2586
• ISSN: 1053-1807
• Language: English
• Keywords: Magnetic Resonance Imaging; Female; Humans; Computer Simulation; Spin Labels; Adult; Male; Cerebrovascular Circulation; Image Processing, Computer-Assisted; Models, Theoretical