Journal article
Direct imaging of the recruitment and phosphorylation of S6K1 in the mTORC1 pathway in living cells
- Abstract:
-
Knowledge of protein signalling pathways in the working cell is seen as a primary route to identifying and developing targeted medicines. In recent years there has been a growing awareness of the importance of the mTOR pathway, making it an attractive target for therapeutic intervention in several diseases. Within this pathway we have focused on S6 kinase 1 (S6K1), the downstream phosphorylation substrate of mTORC1, and specifically identify its juxtaposition with mTORC1. When S6K1 is co-expr...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Bibliographic Details
- Publisher:
- Nature Research Publisher's website
- Journal:
- Scientific Reports Journal website
- Volume:
- 9
- Issue:
- 2019
- Article number:
- 3408
- Publication date:
- 2019-03-04
- Acceptance date:
- 2019-01-23
- DOI:
- ISSN:
-
2045-2322
- Pmid:
-
30833605
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:980873
- UUID:
-
uuid:14443750-f647-40a4-8f83-65b0bfd3a599
- Local pid:
- pubs:980873
- Source identifiers:
-
980873
- Deposit date:
- 2019-04-03
Terms of use
- Copyright holder:
- Ahmed et al
- Copyright date:
- 2019
- Notes:
- © The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
- Licence:
- CC Attribution (CC BY)
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