Journal article
Health-related quality of life at 5 years of age for children born very preterm with congenital anomalies: a multi-national cohort study
- Abstract:
-
Background
This study aimed to investigate the health-related quality of life (HRQoL) at 5 years of age of European children born very preterm across multi-dimensional outcomes by presence and severity of congenital anomalies.Methods
The study used data from a European cohort of children born very preterm (<32 weeks of gestation) and followed up to 5 years of age (N = 3493). Multilevel Ordinary Least Squares (OLS) regression were used to explore the associations between the presence and severity of congenital anomalies.Results
The mean total PedsQL™ GCS score for children with a mild congenital anomaly was lower than the respective value for children without a congenital anomaly by 3.7 points (p < 0.05), controlling for socioeconomic variables only; this effect was attenuated when accumulatively adjusting for perinatal characteristics (3.3 points (p < 0.05)) and neonatal morbidities (3.1 (p < 0.05)). The mean total PedsQL™ GCS scores for children who had a severe congenital anomaly were lower by 7.1 points (p < 0.001), 6.6 points (p< 0.001) and 6.0 points (p < 0.001) when accumulatively adjusting for socioeconomic, perinatal and neonatal variables, respectively.Conclusion
This study revealed that the presence and severity of congenital anomalies are significant predictors of HRQoL outcomes in children born very preterm.
- Publication status:
- Published
- Peer review status:
- Peer reviewed
Actions
Access Document
- Files:
-
-
(Preview, Version of record, pdf, 757.5KB, Terms of use)
-
- Publisher copy:
- 10.1038/s41390-024-03521-9
Authors
- Funder identifier:
- https://ror.org/015ah0c92
- Funding agency for:
- Petrou, S
- Grant:
- NF-SI-0616-10103
- Funder identifier:
- https://ror.org/00k4n6c32
- Grant:
- 633724
- Programme:
- Horizon 2020 Research and Innovation Programme
- Funder identifier:
- https://ror.org/0187kwz08
- Grant:
- NIHR202402
- Publisher:
- Springer Nature
- Journal:
- Pediatric Research More from this journal
- Volume:
- 97
- Issue:
- 5
- Pages:
- 1711-1721
- Publication date:
- 2024-09-07
- Acceptance date:
- 2024-07-25
- DOI:
- EISSN:
-
1530-0447
- ISSN:
-
0031-3998
- Language:
-
English
- Pubs id:
-
2026125
- Local pid:
-
pubs:2026125
- Deposit date:
-
2024-09-08
- ARK identifier:
Terms of use
- Copyright holder:
- Kim et al.
- Copyright date:
- 2024
- Rights statement:
- © The Author(s) 2024. Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.
- Licence:
- CC Attribution (CC BY)
If you are the owner of this record, you can report an update to it here: Report update to this record