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The macrophage F4/80 receptor is required for the induction of antigen-specific efferent regulatory T cells in peripheral tolerance.

Abstract:

We show that the mouse macrophage-restricted F4/80 protein is not required for the development and distribution of tissue macrophages but is involved in the generation of antigen-specific efferent regulatory T (T reg) cells that suppress antigen-specific immunity. In the in vivo anterior chamber (a.c.)-associated immune deviation (ACAID) model of peripheral tolerance, a.c. inoculation of antigen into F4/80(-/-) mice was unable to induce efferent T reg cells and suppress delayed-type hypersens...

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Publication status:
Published

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Publisher copy:
10.1084/jem.20042307

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Journal:
Journal of experimental medicine
Volume:
201
Issue:
10
Pages:
1615-1625
Publication date:
2005-05-01
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
Source identifiers:
22271
Language:
English
Keywords:
Pubs id:
pubs:22271
UUID:
uuid:1423b3a5-ed1a-4679-ba97-b76b0e6ebe08
Local pid:
pubs:22271
Deposit date:
2012-12-19

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