Phentolamine block of KATP channels is mediated by Kir6.2.

Journal article

The ATP-sensitive K+-channel (KATP channel) plays a key role in insulin secretion from pancreatic beta cells. It is closed both by glucose metabolism and the sulfonylurea drugs that are used in the treatment of noninsulin-dependent diabetes mellitus, thereby initiating a membrane depolarization that activates voltage-dependent Ca2+ entry and insulin release. The beta cell KATP channel is a complex of two proteins: Kir6.2 and SUR1. The former is an ATP-sensitive K+-selective pore, whereas SUR1...

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Authors: Proks, P; Ashcroft, F

• Publication status: Published
• Journal: Proceedings of the National Academy of Sciences of the United States of America
• Volume: 94
• Issue: 21
• Pages: 11716-11720
• Publication date: 1997-10-01
• DOI: 10.1073/pnas.94.21.11716
• EISSN: 1091-6490
• ISSN: 0027-8424
• Language: English
• Keywords: Oocytes; Sequence Deletion; Humans; ATP-Binding Cassette Transporters; Imidazoles; Mice; Recombinant Proteins; Animals; Potassium Channels; Cell Line; Phentolamine; Potassium Channels, Inwardly Rectifying; Membrane Potentials; Potassium Channel Blockers; Xenopus; Transfection; Female