Nitric oxide control of cardiac function: is neuronal nitric oxide synthase a key component?

Journal article

Nitric oxide (NO) has been shown to regulate cardiac function, both in physiological conditions and in disease states. However, several aspects of NO signalling in the myocardium remain poorly understood. It is becoming increasingly apparent that the disparate functions ascribed to NO result from its generation by different isoforms of the NO synthase (NOS) enzyme, the varying subcellular localization and regulation of NOS isoforms and their effector proteins. Some apparently contrasting find...

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Authors: Sears, C; Ashley, E; Casadei, B

• Publication status: Published
• Journal: Philosophical transactions of the Royal Society of London. Series B, Biological sciences
• Volume: 359
• Issue: 1446
• Pages: 1021-1044
• Publication date: 2004-06-01
• DOI: 10.1098/rstb.2004.1477
• EISSN: 1471-2970
• ISSN: 0962-8436
• Language: English
• Keywords: Myocardial Contraction; Nitric Oxide; Biological Transport, Active; Nitric Oxide Synthase Type I; Autonomic Nervous System; Neurons; Signal Transduction; Models, Biological; Isoenzymes; Humans; Heart Rate; Baroreflex; Nitric Oxide Synthase; Myocardium; Heart