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Journal article

miR-375 maintains normal pancreatic alpha- and beta-cell mass.

Abstract:

Altered growth and development of the endocrine pancreas is a frequent cause of the hyperglycemia associated with diabetes. Here we show that microRNA-375 (miR-375), which is highly expressed in pancreatic islets, is required for normal glucose homeostasis. Mice lacking miR-375 (375KO) are hyperglycemic, exhibit increased total pancreatic alpha-cell numbers, fasting and fed plasma glucagon levels, and increased gluconeogenesis and hepatic glucose output. Furthermore, pancreatic beta-cell mass...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0810550106

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Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
106
Issue:
14
Pages:
5813-5818
Publication date:
2009-04-05
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
URN:
uuid:13f56435-0e3e-47c6-b5b1-f50e893053c2
Source identifiers:
14791
Local pid:
pubs:14791

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