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Effect of G-tract length on the topology and stability of intramolecular DNA quadruplexes.

Abstract:

G-Rich sequences are known to form four-stranded structures that are based on stacks of G-quartets, and sequences with the potential to adopt these structures are common in eukaryotic genomes. However, there are few rules for predicting the relative stability of folded complexes that are adopted by sequences with different-length G-tracts or variable-length linkers between them. We have used thermal melting, circular dichroism, and gel electrophoresis to examine the topology and stability of ...

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Publication status:
Published

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Publisher copy:
10.1021/bi062118j

Authors


Rachwal, PA More by this author
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Institution:
University of Oxford
Department:
Oxford, MPLS, Chemistry, Organic Chemistry
Journal:
Biochemistry
Volume:
46
Issue:
11
Pages:
3036-3044
Publication date:
2007-03-05
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
URN:
uuid:13f547f2-2eee-4384-9957-e633f525cf4f
Source identifiers:
400030
Local pid:
pubs:400030

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