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Effect of G-tract length on the topology and stability of intramolecular DNA quadruplexes.

Abstract:

G-Rich sequences are known to form four-stranded structures that are based on stacks of G-quartets, and sequences with the potential to adopt these structures are common in eukaryotic genomes. However, there are few rules for predicting the relative stability of folded complexes that are adopted by sequences with different-length G-tracts or variable-length linkers between them. We have used thermal melting, circular dichroism, and gel electrophoresis to examine the topology and stability of ...

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Publication status:
Published

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Publisher copy:
10.1021/bi062118j

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
Journal:
Biochemistry
Volume:
46
Issue:
11
Pages:
3036-3044
Publication date:
2007-03-01
DOI:
EISSN:
1520-4995
ISSN:
0006-2960
Source identifiers:
400030
Language:
English
Keywords:
Pubs id:
pubs:400030
UUID:
uuid:13f547f2-2eee-4384-9957-e633f525cf4f
Local pid:
pubs:400030
Deposit date:
2013-11-16

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