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Journal article

Selective nucleotide-release from dense-core granules in insulin-secreting cells.

Abstract:

Secretory granules of insulin-secreting cells are used to store and release peptide hormones as well as low-molecular-weight compounds such as nucleotides. Here we have compared the rate of exocytosis with the time courses of nucleotide and peptide release by a combination of capacitance measurements, electrophysiological detection of ATP release and single-granule imaging. We demonstrate that the release of nucleotides and peptides is delayed by approximately 0.1 and approximately 2 seconds ...

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Publication status:
Published

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Publisher copy:
10.1242/jcs.02549

Authors


Obermüller, S More by this author
Lindqvist, A More by this author
Karanauskaite, J More by this author
Galvanovskis, J More by this author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, RDM, OCDEM
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Journal:
Journal of cell science
Volume:
118
Issue:
Pt 18
Pages:
4271-4282
Publication date:
2005-09-05
DOI:
EISSN:
1477-9137
ISSN:
0021-9533
URN:
uuid:13f3577e-b952-4c6d-9a06-2817fd555e62
Source identifiers:
18272
Local pid:
pubs:18272

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