- Abstract:
-
Secretory granules of insulin-secreting cells are used to store and release peptide hormones as well as low-molecular-weight compounds such as nucleotides. Here we have compared the rate of exocytosis with the time courses of nucleotide and peptide release by a combination of capacitance measurements, electrophysiological detection of ATP release and single-granule imaging. We demonstrate that the release of nucleotides and peptides is delayed by approximately 0.1 and approximately 2 seconds ...
Expand abstract - Publication status:
- Published
- Publisher copy:
- 10.1242/jcs.02549
-
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- Journal:
- Journal of cell science
- Volume:
- 118
- Issue:
- Pt 18
- Pages:
- 4271-4282
- Publication date:
- 2005-09-05
- DOI:
- EISSN:
-
1477-9137
- ISSN:
-
0021-9533
- URN:
-
uuid:13f3577e-b952-4c6d-9a06-2817fd555e62
- Source identifiers:
-
18272
- Local pid:
- pubs:18272
- Language:
- English
- Keywords:
- Copyright date:
- 2005
Journal article
Selective nucleotide-release from dense-core granules in insulin-secreting cells.
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