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The mystery of membrane organization: composition, regulation and roles of lipid rafts.

Abstract:

Cellular plasma membranes are laterally heterogeneous, featuring a variety of distinct subcompartments that differ in their biophysical properties and composition. A large number of studies have focused on understanding the basis for this heterogeneity and its physiological relevance. The membrane raft hypothesis formalized a physicochemical principle for a subtype of such lateral membrane heterogeneity, in which the preferential associations between cholesterol and saturated lipids drive the...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Accepted manuscript

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Publisher copy:
10.1038/nrm.2017.16

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Department:
Oxford, MSD, RDM, RDM - Investigative Medicine Division
Role:
Author
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Department:
Oxford, MSD, RDM, RDM - Investigative Medicine Division
Role:
Author
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Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Reviews Molecular Cell Biology Journal website
Volume:
18
Pages:
361-374
Publication date:
2017-05-05
DOI:
EISSN:
1471-0080
ISSN:
1471-0072
Pubs id:
pubs:688811
URN:
uri:13f238a4-d541-44ca-a3bd-07850dd1e449
UUID:
uuid:13f238a4-d541-44ca-a3bd-07850dd1e449
Local pid:
pubs:688811
Language:
English
Keywords:

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