Journal article

The mystery of membrane organization: composition, regulation and roles of lipid rafts.

Abstract:: Cellular plasma membranes are laterally heterogeneous, featuring a variety of distinct subcompartments that differ in their biophysical properties and composition. A large number of studies have focused on understanding the basis for this heterogeneity and its physiological relevance. The membrane raft hypothesis formalized a physicochemical principle for a subtype of such lateral membrane heterogeneity, in which the preferential associations between cholesterol and saturated lipids drive the formation of relatively packed (or ordered) membrane domains that selectively recruit certain lipids and proteins. Recent studies have yielded new insights into this mechanism and its relevance in vivo, owing primarily to the development of improved biochemical and biophysical technologies.

Publication status:: Published

Peer review status:: Peer reviewed

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APA Style

Sezgin, E., Levental, I., Mayor, S., & Eggeling, C. (2017). The mystery of membrane organization: composition, regulation and roles of lipid rafts. Nature Reviews Molecular Cell Biology, 18, 361–374.

MLA Style

Sezgin, E, et al. “The Mystery of Membrane Organization: Composition, Regulation and Roles of Lipid Rafts.” Nature Reviews Molecular Cell Biology, vol. 18, 2017, pp. 361–74.

Chicago Style

Sezgin, E, I Levental, S Mayor, and C Eggeling. 2017. “The Mystery of Membrane Organization: Composition, Regulation and Roles of Lipid Rafts.” Nature Reviews Molecular Cell Biology 18: 361–74.
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Files:: Sezgin et al, The mystery of membrane organization - compositi...

(Preview, Accepted manuscript, pdf, 513.0KB, Terms of use)

Publisher copy:: 10.1038/nrm.2017.16

Authors

+ Sezgin, E More by this author

Institution:: University of Oxford
Division:: MSD
Department:: RDM
Sub department:: RDM - Investigative Medicine Division
Role:: Author

+ Levental, I More by this author

Role:: Author

+ Mayor, S More by this author

Role:: Author

+ Eggeling, C More by this author

Institution:: University of Oxford
Division:: MSD
Department:: RDM
Sub department:: RDM - Investigative Medicine Division
Role:: Author

+ National Institutes of Health More from this funder

Grant:: 1R01GM114282

+ Serbian Department of Science and Technology More from this funder

Grant:: JC Bose fellowship

+ Marie Curie Intra-European Fellowships More from this funder

Grant:: MEMBRANE DYNAMICS

+ Wellcome Trust More from this funder

Grant:: IA/M/15/1/502018

+ European Molecular Biology Organization More from this funder

Grant:: ALTF 636-2013

More funders...

Publisher:: Nature Publishing Group
Journal:: Nature Reviews Molecular Cell Biology More from this journal
Volume:: 18
Pages:: 361-374
Publication date:: 2017-05-01
DOI:: 10.1038/nrm.2017.16
EISSN:: 1471-0080
ISSN:: 1471-0072

Language:: English
Keywords:: Journal Article

Review
Pubs id:: pubs:688811
UUID:: uuid:13f238a4-d541-44ca-a3bd-07850dd1e449
Local pid:: pubs:688811
Source identifiers:: 688811
Deposit date:: 2017-05-11
ARK identifier:: ark:/29072/ora_13f238a4d54144caa3bd07850dd1e449

Terms of use

Copyright holder:: Macmillan Publishers Limited
Copyright date:: 2017
Notes:: © 2017 Macmillan Publishers Limited, part of Springer Nature. All rights reserved

Licence:: Terms and Conditions of Use for Oxford University Research Archive

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