Brain wiring depends on cells making highly localized and selective connections through surface protein-protein interactions, including those between NetrinGs and NetrinG ligands (NGLs). The NetrinGs are members of the structurally uncharacterized netrin family. We present a comprehensive crystallographic analysis comprising NetrinG1-NGL1 and NetrinG2-NGL2 complexes, unliganded NetrinG2 and NGL3. Cognate NetrinG-NGL interactions depend on three specificity-conferring NetrinG loops, clasped ti...Expand abstract
- Publication status:
- Publisher copy:
- Copyright date:
Structural basis for cell surface patterning through NetrinG-NGL interactions.
If you are the owner of this record, you can report an update to it here: Report update to this record