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Journal article

Structural basis for cell surface patterning through NetrinG-NGL interactions.

Abstract:

Brain wiring depends on cells making highly localized and selective connections through surface protein-protein interactions, including those between NetrinGs and NetrinG ligands (NGLs). The NetrinGs are members of the structurally uncharacterized netrin family. We present a comprehensive crystallographic analysis comprising NetrinG1-NGL1 and NetrinG2-NGL2 complexes, unliganded NetrinG2 and NGL3. Cognate NetrinG-NGL interactions depend on three specificity-conferring NetrinG loops, clasped ti...

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Publication status:
Published

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Publisher copy:
10.1038/emboj.2011.346

Authors


Seiradake, E More by this author
Perestenko, PV More by this author
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Institution:
University of Oxford
Department:
Oxford, MSD, Pharmacology
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Journal:
The EMBO journal
Volume:
30
Issue:
21
Pages:
4479-4488
Publication date:
2011-11-05
DOI:
EISSN:
1460-2075
ISSN:
0261-4189
URN:
uuid:13ed888b-1915-456e-88c0-5b17240c5dbe
Source identifiers:
180452
Local pid:
pubs:180452

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