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Dissociable effects of 6-OHDA-induced lesions of neostriatum on anorexia, locomotor activity and stereotypy: the role of behavioural competition.

Abstract:

The effect of 6-OHDA-induced lesions of neostriatum on locomotor activity, stereotypy and anorexia induced by amphetamine (0.5 mg/kg, 1.5 mg/kg and 5.0 mg/kg IP) was examined. Lesioned rats demonstrated attenuated stereotypy and anorexia but enhanced locomotor activity to amphetamine. Biochemical analysis of dopamine and noradrenaline in specific forebrain areas demonstrated significant dopamine depletion in neostriatum. Dopamine levels in mesolimbic, frontal cortex and hypothalamic areas, an...

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Publication status:
Published

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Publisher copy:
10.1007/bf00428546

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Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
Journal:
Psychopharmacology
Volume:
83
Issue:
4
Pages:
363-366
Publication date:
1984-01-01
DOI:
EISSN:
1432-2072
ISSN:
0033-3158
Source identifiers:
21137
Language:
English
Keywords:
Pubs id:
pubs:21137
UUID:
uuid:13ecf676-89c5-4039-a1d4-7dd5ac58ccaa
Local pid:
pubs:21137
Deposit date:
2012-12-19

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