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Activation-induced killer cell immunoglobulin-like receptor 3DL2 binding to HLA-B27 licenses pathogenic T cell differentiation in spondyloarthritis

Abstract:

In the spondyloarthritides (SpA), increased numbers of CD4+ T cells express killer cell immunoglobulin-like receptor 3DL2 (KIR-3DL2). The aim of this study was to determine the factors that induce KIR-3DL2 expression, and to characterize the relationship between HLA-B27 and the phenotype and function of KIR-3DL2-expressing CD4+ T cells in SpA.In total, 34 B27+ patients with SpA, 28 age- and sex-matched healthy controls (20 B27- and 8 B27+), and 9 patients with rheumatoid arthritis were studie...

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Publication status:
Published
Peer review status:
Peer reviewed
Version:
Publisher's version

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Publisher copy:
10.1002/art.39515

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Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Oxford, MSD, NDORMS
Role:
Author
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Publisher:
Wiley Publisher's website
Journal:
Arthritis and Rheumatology Journal website
Volume:
68
Issue:
4
Pages:
901-914
Publication date:
2016-01-01
DOI:
EISSN:
2326-5205
ISSN:
2326-5191
URN:
uuid:13ebc6f7-6ffa-4f2a-a859-7800c7394610
Source identifiers:
601440
Local pid:
pubs:601440
Paper number:
4
Language:
English
Keywords:

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