Intrapleural agents for pleural infection: fibrinolytics and beyond.

Journal article

PURPOSE OF REVIEW: Pleural infection is a common, increasing clinical problem with a high morbidity and mortality. Medical management of pleural infection often fails, requiring invasive thoracic surgery to drain infected pleural collections, and for many years intrapleural agents have been assessed to reduce the need for surgical drainage and improve clinical outcomes. Randomized trials assessing intrapleural fibrinolytic agents have given conflicting results, and recent evidence provides i...

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Authors: Rahman, N

• Publication status: Published
• Journal: Current opinion in pulmonary medicine
• Volume: 18
• Issue: 4
• Pages: 326-332
• Publication date: 2012-07-01
• DOI: 10.1097/mcp.0b013e3283531149
• EISSN: 1531-6971
• ISSN: 1070-5287
• Language: English
• Keywords: Tissue Plasminogen Activator; Pleural Diseases; Combined Modality Therapy; Deoxyribonucleases; Humans; Thrombolytic Therapy; Drainage; Child, Preschool; Randomized Controlled Trials as Topic; Fibrinolytic Agents; Pleura; Adult; Child