Phase I/IIa study to assess the safety, immunogenicity and efficacy of ChAdOx1-MVA vectored vaccines expressing a novel liver-stage malaria dual antigen LS2 by sporozoite challenge in malaria-naïve adults [version 2; peer review: 2 approved]

Silman, D; Flaxman, A; Datoo, M; Edwards, NJ; Ramos-Lopez, F; Mitton, C; Mair, C; Bellamy, D; Bowyer, G; Morter, R; Halbroth, B; Venkatraman, N; Folegatti, PM; Marshall, J; Poulton, I; Bajer, A; Salman, AM; Berrie, E; Baum, J; Blagborough, AM; Crocker, W; Roberts, R; Lawrie, AM; Spencer, AJ; Gilbert, SC; Ewer, KJ; Hill, AVS

Journal article

Phase I/IIa study to assess the safety, immunogenicity and efficacy of ChAdOx1-MVA vectored vaccines expressing a novel liver-stage malaria dual antigen LS2 by sporozoite challenge in malaria-naïve adults [version 2; peer review: 2 approved]

Publication status:: Published

Peer review status:: Peer reviewed

Actions

Email

Email this record

Send the bibliographic details of this record to your email address.

Your Email
Please enter the email address that the record information will be sent to.

-
Your message (optional)
Please add any additional information to be included within the email.
Share
Cite

Cite this record

APA Style

Silman, D., Flaxman, A., Datoo, M., Edwards, N. J., Ramos-Lopez, F., Mitton, C., Mair, C., Bellamy, D., Bowyer, G., Morter, R., Halbroth, B., Venkatraman, N., Folegatti, P. M., Marshall, J., Poulton, I., Bajer, A., Salman, A. M., Berrie, E., Baum, J., … Hill, A. V. S. (2024). Phase I/IIa study to assess the safety, immunogenicity and efficacy of ChAdOx1-MVA vectored vaccines expressing a novel liver-stage malaria dual antigen LS2 by sporozoite challenge in malaria-naïve adults [version 2; peer review: 2 approved]. Wellcome Open Research, 9.

MLA Style

Silman, D, et al. “Phase I/IIa Study to Assess the Safety, Immunogenicity and Efficacy of ChAdOx1-MVA Vectored Vaccines Expressing a Novel Liver-Stage Malaria Dual Antigen LS2 by Sporozoite Challenge in Malaria-Naïve Adults [Version 2; Peer Review: 2 Approved].” Wellcome Open Research, vol. 9, 2024.

Chicago Style

Silman, D, A Flaxman, M Datoo, et al. 2024. “Phase I/IIa Study to Assess the Safety, Immunogenicity and Efficacy of ChAdOx1-MVA Vectored Vaccines Expressing a Novel Liver-Stage Malaria Dual Antigen LS2 by Sporozoite Challenge in Malaria-Naïve Adults [Version 2; Peer Review: 2 Approved].” Wellcome Open Research 9.
Print

Access Document

Files:: Silman_et_al_2024_Phase_I_IIa_study.pdf

(Preview, Version of record, pdf, 1.9MB, Terms of use)

Publisher copy:: 10.12688/wellcomeopenres.22900.2

Authors

+ Silman, D More by this author

Institution:: University of Oxford
Division:: MSD
Department:: NDM
Sub department:: Jenner Institute
Role:: Author

+ Flaxman, A More by this author

Institution:: University of Oxford
Division:: MSD
Department:: NDM
Sub department:: Jenner Institute
Role:: Author

+ Datoo, M More by this author

Institution:: University of Oxford
Division:: MSD
Department:: NDM
Sub department:: Jenner Institute
Role:: Author

+ Edwards, NJ More by this author

Institution:: University of Oxford
Division:: MSD
Department:: NDM
Sub department:: Jenner Institute
Role:: Author

+ Ramos-Lopez, F More by this author

Institution:: University of Oxford
Division:: MSD
Department:: NDM
Sub department:: Jenner Institute
Role:: Author

More authors...

+ European Commission More from this funder

Funder identifier:: https://ror.org/00k4n6c32

Publisher:: Taylor and Francis
Journal:: Wellcome Open Research More from this journal
Volume:: 9
Publication date:: 2024-01-01
Acceptance date:: 2026-03-19
DOI:: 10.12688/wellcomeopenres.22900.2
EISSN:: 2398502X
ISSN:: 2398502X

Language:: English
Keywords:: P. Falciparum; Malaria; Vaccines; Chmi; T Cells; Adenovirus; Mva; Viral Vectors
Pubs id:: 2404669
Local pid:: pubs:2404669
Source identifiers:: 3964892
Deposit date:: 2026-04-21
ARK identifier:: ark:/29072/ora_13d9efd4d5c44fa68fab5fa251c968e0

Terms of use

Licence:: CC Attribution (CC BY)

Views and Downloads

About views and downloads

If you are the owner of this record, you can report an update to it here: Report update to this record

Journal article

Phase I/IIa study to assess the safety, immunogenicity and efficacy of ChAdOx1-MVA vectored vaccines expressing a novel liver-stage malaria dual antigen LS2 by sporozoite challenge in malaria-naïve adults [version 2; peer review: 2 approved]

Actions

Access Document

Authors

Terms of use

Views and Downloads

Altmetrics

Dimensions

Journal article

Phase I/IIa study to assess the safety, immunogenicity and efficacy of ChAdOx1-MVA vectored vaccines expressing a novel liver-stage malaria dual antigen LS2 by sporozoite challenge in malaria-naïve adults [version 2; peer review: 2 approved]

Actions

Access Document

Authors

Funding

Bibliographic Details

Item Description

Terms of use

Metrics

Views and Downloads

Altmetrics

Dimensions