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CRAC channels drive digital activation and provide analog control and synergy to Ca 2+-dependent gene regulation

Abstract:

Ca 2+-dependent gene expression is critical for cell growth, proliferation, plasticity, and adaptation [1-3]. Because a common mechanism in vertebrates linking cytoplasmic Ca 2+ signals with activation of protein synthesis involves the nuclear factor of activated T cells (NFAT) family of transcription factors [4, 5], we have quantified protein expression in single cells following physiological Ca 2+ signals by using NFAT-driven expression of a genetically encoded fluorescent protein. We find ...

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Publisher copy:
10.1016/j.cub.2011.12.025

Authors


Journal:
Current Biology
Volume:
22
Issue:
3
Pages:
242-247
Publication date:
2012-02-07
DOI:
ISSN:
0960-9822
Source identifiers:
316685
Language:
English
Pubs id:
pubs:316685
UUID:
uuid:13d9a960-d653-4014-be3f-3e2eac0984ad
Local pid:
pubs:316685
Deposit date:
2012-12-19

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