Journal article
CRAC channels drive digital activation and provide analog control and synergy to Ca 2+-dependent gene regulation
- Abstract:
-
Ca 2+-dependent gene expression is critical for cell growth, proliferation, plasticity, and adaptation [1-3]. Because a common mechanism in vertebrates linking cytoplasmic Ca 2+ signals with activation of protein synthesis involves the nuclear factor of activated T cells (NFAT) family of transcription factors [4, 5], we have quantified protein expression in single cells following physiological Ca 2+ signals by using NFAT-driven expression of a genetically encoded fluorescent protein. We find ...
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- Publisher copy:
- 10.1016/j.cub.2011.12.025
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Bibliographic Details
- Journal:
- Current Biology
- Volume:
- 22
- Issue:
- 3
- Pages:
- 242-247
- Publication date:
- 2012-02-07
- DOI:
- ISSN:
-
0960-9822
- Source identifiers:
-
316685
Item Description
- Language:
- English
- Pubs id:
-
pubs:316685
- UUID:
-
uuid:13d9a960-d653-4014-be3f-3e2eac0984ad
- Local pid:
- pubs:316685
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2012
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